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Functional Blocking Monoclonal Antibodies against IL-12p40 Homodimer Inhibit Adoptive Transfer of Experimental Allergic Encephalomyelitis

IL-12p70 (p40:p35) and IL-23 (p40:p19) are bioactive cytokines and their role in experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis, are becoming clear. On the other hand, the IL-12p40 homodimer (p40(2)) was considered as an inactive or inhibitory molecule and its...

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Main Authors: Mondal, Susanta, Roy, Avik, Pahan, Kalipada
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721330/
https://ncbi.nlm.nih.gov/pubmed/19342681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0801734
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