DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer

The acquisition of resistance is a major obstacle to the clinical use of platinum drugs for ovarian cancer treatment. Increase of DNA damage response is one of major mechanisms contributing to platinum-resistance. However, how DNA damage response is regulated in platinum-resistant ovarian cancer cel...

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Udgivet i:Cancer Lett
Main Authors: Meng, Yunxiao, Chen, Chi-Wei, Sun, Wei, Yung, Mingo MH, Zhou, Wei, Li, Jing, Sun, Jing, Li, Zhuqing, Li, Zongzhu, Liu, Stephanie S, Cheung, Annie NY, Ngan, Hextan YS, Braisted, John C., Kai, Yan, Peng, Weiqun, Tzatsos, Alexandros, Li, Yiliang, Dai, Zhijun, Zheng, Wei, Chan, David W., Zhu, Wenge
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474466/
https://ncbi.nlm.nih.gov/pubmed/29704517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.04.029
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