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Multiscale Simulation Reveals Passive Proton Transport Through SERCA on the Microsecond Timescale

The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) transports two Ca(2+) ions from the cytoplasm to the reticulum lumen at the expense of ATP hydrolysis. In addition to transporting Ca(2+), SERCA facilitates bidirectional proton transport across the sarcoplasmic reticulum to maintain the charge balanc...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Li, Chenghan, Yue, Zhi, Espinoza-Fonseca, L. Michel, Voth, Gregory A.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474205/
https://ncbi.nlm.nih.gov/pubmed/32814059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.07.027
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