Upregulated proteoglycan-related signaling pathways in fluid flow shear stress-treated podocytes

The ultrafiltrate flow over the major processes and cell body generates fluid flow shear stress (FFSS) on podocytes. Hyperfiltration-associated increase in FFSS can lead to podocyte injury and detachment. Previously, we showed that FFSS-induced upregulation of the cyclooxygenase 2 (COX2)-PGE(2)-pros...

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Udgivet i:Am J Physiol Renal Physiol
Main Authors: Srivastava, Tarak, Joshi, Trupti, Jiang, Yuexu, Heruth, Daniel P., Rezaiekhaligh, Mohamed H., Novak, Jan, Staggs, Vincent S., Alon, Uri S., Garola, Robert E., El-Meanawy, Ashraf, McCarthy, Ellen T., Zhou, Jianping, Boinpelly, Varun C., Sharma, Ram, Savin, Virginia J., Sharma, Mukut
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473905/
https://ncbi.nlm.nih.gov/pubmed/32628542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00183.2020
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