Synthesis and biological evaluation of hapten-clicked analogues of the antigenic peptide Melan-A/MART-1(26(27L)-35)

A click chemistry-based approach was implemented to prepare peptidomimetics designed in silico and made from aromatic azides and a propargylated GIGI-mimicking platform derived from the altered Melan-A/MART-1(26(27L)-35) antigenic peptide ELAGIGILTV. The Cu(I)-catalyzed Huisgen cycloaddition was car...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Tarbe, Marion, Miles, John J., Edwards, Emily S. J., Miles, Kim M., Sewell, Andrew K., Baker, Brian M., Quideau, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473458/
https://ncbi.nlm.nih.gov/pubmed/32162475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000038
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