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Crystal structures of HLA-A*0201 complexed with Melan-A/MART-1(26(27L)-35) peptidomimetics reveal conformational heterogeneity and highlight degeneracy of T cell recognition

There is growing interest in using tumor associated antigens presented by class-I major histocompatibility complex (MHC-I) proteins as cancer vaccines. As native peptides are poorly stable in biological fluids, researchers have sought to engineer synthetic peptidomimetics with greater biostability....

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書誌詳細
主要な著者: Douat-Casassus, Céline, Borbulevych, Oleg, Tarbe, Marion, Gervois, Nadine, Jotereau, Francine, Baker, Brian M., Quideau, Stéphane
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951488/
https://ncbi.nlm.nih.gov/pubmed/20806940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100683p
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