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Structures of MART-1(26/27–35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition

Small structural changes in peptides presented by major histocompatibility complex (MHC) molecules often result in large changes in immunogenicity, supporting the notion that T cell receptors are exquisitely sensitive to antigen structure. Yet there are striking examples of TCR recognition of struct...

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Bibliografske podrobnosti
Main Authors: Borbulevych, Oleg Y., Insaidoo, Francis K., Baxter, Tiffany K., Powell, Daniel J., Johnson, Laura A., Restifo, Nicholas P., Baker, Brian M.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2134917/
https://ncbi.nlm.nih.gov/pubmed/17719062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.07.025
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