Metformin attenuates renal interstitial fibrosis through upregulation of Deptor in unilateral ureteral obstruction in rats

Renal interstitial fibrosis (RIF) is a common pathological process that accompanies chronic kidney disease (CKD) and that progresses to end-stage renal failure (ESRD). Accumulating evidence has revealed that persistent mammalian target of rapamycin (mTOR) activation in kidneys is closely associated...

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Udgivet i:Exp Ther Med
Main Authors: Wang, Yanxia, Wang, Yan, Li, Yong, Lu, Linghong, Peng, Yingxian, Zhang, Shu, Xia, Anzhou
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471900/
https://ncbi.nlm.nih.gov/pubmed/32934682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2020.9144
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