Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice

Renal fibrosis cannot be adequately treated since anti-fibrotic treatment is lacking. Interferon-γ is a pro-inflammatory cytokine with anti-fibrotic properties. Clinical use of interferon-γ is hampered due to inflammation-mediated systemic side effects. We used an interferon-γ peptidomimetic (mimγ)...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Poosti, Fariba, Bansal, Ruchi, Yazdani, Saleh, Prakash, Jai, Beljaars, Leonie, van den Born, Jacob, de Borst, Martin H., van Goor, Harry, Hillebrands, Jan-Luuk, Poelstra, Klaas
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342338/
https://ncbi.nlm.nih.gov/pubmed/27509062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11095
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