MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes

BACKGROUND: Microsatellite instability (MSI) has emerged as a predictive biomarker for immune checkpoint inhibitor therapy. Cancer heterogeneity represents a potential obstacle for the analysis of predicitive biomarkers. MSI has been reported in pancreatic cancer, but data on the possible extent of...

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Detalhes bibliográficos
Publicado no:Ann Surg Oncol
Main Authors: Fraune, Christoph, Burandt, Eike, Simon, Ronald, Hube-Magg, Claudia, Makrypidi-Fraune, Georgia, Kluth, Martina, Büscheck, Franziska, Höflmayer, Doris, Blessin, Niclas Ch., Mandelkow, Tim, Li, Wenchao, Perez, Daniel, Izbicki, Jakob R., Wilczak, Waldemar, Sauter, Guido, Schrader, Jörg, Neipp, Michael, Mofid, Hamid, Daniels, Thies, Isbert, Christoph, Clauditz, Till S., Steurer, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Translational Research and Biomarkers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471097/
https://ncbi.nlm.nih.gov/pubmed/32108923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-020-08209-y
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