Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway

β-amyloid (Aβ) is one of the inducing factors of astrocytes activation and neuroinflammation, and it is also a crucial factor for the development of Alzheimer’s disease (AD). Icariside II (ICS II) is an active component isolated from a traditional Chinese herb Epimedium, which has shown to attnuate...

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Bibliographic Details
Published in:Acta Pharmacol Sin
Main Authors: Zheng, Yong, Deng, Yan, Gao, Jian-mei, Lv, Chun, Lang, Ling-hu, Shi, Jing-shan, Yu, Chang-yin, Gong, Qi-hai
Format: Artigo
Language:Inglês
Published: Springer Singapore 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470889/
https://ncbi.nlm.nih.gov/pubmed/31554962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0300-2
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