Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors

In this paper, a new series of isatin-sulphonamide based derivatives were designed, synthesised and evaluated as caspase inhibitors. The compounds containing 1-(pyrrolidinyl)sulphonyl and 2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl substitution at C5 position of isatin core exhibited better results c...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Firoozpour, Loghman, Gao, Lixin, Moghimi, Setareh, Pasalar, Parvin, Davoodi, Jamshid, Wang, Ming-Wei, Rezaei, Zahra, Dadgar, Armin, Yahyavi, Hoda, Amanlou, Massoud, Foroumadi, Alireza
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470124/
https://ncbi.nlm.nih.gov/pubmed/32842789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1809388
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