Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison

In this study, some benzimidazole-oxadiazole derivatives were synthesised and tested for their in vitro anticancer activities on five cancer cell lines, including HeLa, MCF7, A549, HepG2 and C6. Their structures were elucidated by IR, (1)H-NMR, (13)C-NMR, 2 D-NMR and HRMS spectroscopic methods. Amon...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Acar Çevik, Ulviye, Sağlık, Begüm Nurpelin, Osmaniye, Derya, Levent, Serkan, Kaya Çavuşoğlu, Betül, Karaduman, Abdullah Burak, Atlı Eklioğlu, Özlem, Özkay, Yusuf, Kaplancıklı, Zafer Asım
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470102/
https://ncbi.nlm.nih.gov/pubmed/32811204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1806831
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