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Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors – design, synthesis, biological evaluation and molecular modelling

Monoamine oxidases (MAOs) are important drug targets for the management of neurological disorders. Herein, a series of new 1,3,4-thiadiazole derivatives bearing various alkyl/arylamine moieties as MAO inhibitors were designed and synthesized. All of the compounds were more selective against hMAO-A t...

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Detalhes bibliográficos
Publicado no:RSC Med Chem
Main Authors: Sağlık, Begüm Nurpelin, Kaya Çavuşoğlu, Betül, Acar Çevik, Ulviye, Osmaniye, Derya, Levent, Serkan, Özkay, Yusuf, Kaplancıklı, Zafer Asım
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513386/
https://ncbi.nlm.nih.gov/pubmed/33479699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00150c
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