Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors

Alveolar epithelial type 2 cells (AEC2s) are the facultative progenitors responsible for maintaining lung alveoli throughout life, but are difficult to isolate from patients. Here we engineer AEC2s from human pluripotent stem cells in vitro and use time-series single-cell RNA sequencing with lentivi...

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Publicado no:Cell Stem Cell
Main Authors: Hurley, Killian, Ding, Jun, Villacorta-Martin, Carlos, Herriges, Michael J., Jacob, Anjali, Vedaie, Marall, Alysandratos, Konstantinos D., Sun, Yuliang L., Lin, Chieh, Werder, Rhiannon B., Huang, Jessie, Wilson, Andrew A., Mithal, Aditya, Mostoslavsky, Gustavo, Oglesby, Irene, Caballero, Ignacio S., Guttentag, Susan H., Ahangari, Farida, Kaminski, Naftali, Rodriguez-Fraticelli, Alejo, Camargo, Fernando, Bar-Joseph, Ziv, Kotton, Darrell N
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469703/
https://ncbi.nlm.nih.gov/pubmed/32004478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.12.009
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