Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors

Development of an anti-SARS-CoV-2 therapeutic is hindered by the lack of physiologically relevant model systems that can recapitulate host-viral interactions in human cell types, specifically the epithelium of the lung. Here, we compare induced pluripotent stem cell (iPSC)-derived alveolar and airwa...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Abo, Kristine M., Ma, Liang, Matte, Taylor, Huang, Jessie, Alysandratos, Konstantinos D., Werder, Rhiannon B., Mithal, Aditya, Beermann, Mary Lou, Lindstrom-Vautrin, Jonathan, Mostoslavsky, Gustavo, Ikonomou, Laertis, Kotton, Darrell N., Hawkins, Finn, Wilson, Andrew, Villacorta-Martin, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7302183/
https://ncbi.nlm.nih.gov/pubmed/32577635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.03.132639
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