Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed that, in hypothalamic neuronal cells, exposure to PA inhibits the autophagic f...

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Vydáno v:Mol Cell Oncol
Hlavní autoři: Hernández-Cáceres, María Paz, Cereceda, Karina, Hernández, Sergio, Li, Ying, Narro, Carla, Rivera, Patricia, Silva, Patricio, Ávalos, Yenniffer, Jara, Claudia, Burgos, Paulina, Toledo-Valenzuela, Lilian, Lagos, Pablo, Cifuentes Araneda, Flavia, Perez-Leighton, Claudio, Bertocchi, Cristina, Clegg, Deborah J., Criollo, Alfredo, Tapia-Rojas, Cheril, Burgos, Patricia V., Morselli, Eugenia
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469685/
https://ncbi.nlm.nih.gov/pubmed/32944643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1789418
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