Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed that, in hypothalamic neuronal cells, exposure to PA inhibits the autophagic f...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell Oncol
Asıl Yazarlar: Hernández-Cáceres, María Paz, Cereceda, Karina, Hernández, Sergio, Li, Ying, Narro, Carla, Rivera, Patricia, Silva, Patricio, Ávalos, Yenniffer, Jara, Claudia, Burgos, Paulina, Toledo-Valenzuela, Lilian, Lagos, Pablo, Cifuentes Araneda, Flavia, Perez-Leighton, Claudio, Bertocchi, Cristina, Clegg, Deborah J., Criollo, Alfredo, Tapia-Rojas, Cheril, Burgos, Patricia V., Morselli, Eugenia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2020
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469685/
https://ncbi.nlm.nih.gov/pubmed/32944643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1789418
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