Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed that, in hypothalamic neuronal cells, exposure to PA inhibits the autophagic f...

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Foilsithe in:Mol Cell Oncol
Main Authors: Hernández-Cáceres, María Paz, Cereceda, Karina, Hernández, Sergio, Li, Ying, Narro, Carla, Rivera, Patricia, Silva, Patricio, Ávalos, Yenniffer, Jara, Claudia, Burgos, Paulina, Toledo-Valenzuela, Lilian, Lagos, Pablo, Cifuentes Araneda, Flavia, Perez-Leighton, Claudio, Bertocchi, Cristina, Clegg, Deborah J., Criollo, Alfredo, Tapia-Rojas, Cheril, Burgos, Patricia V., Morselli, Eugenia
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2020
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469685/
https://ncbi.nlm.nih.gov/pubmed/32944643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1789418
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