ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

Autophagy, an important catabolic pathway implicated in a broad spectrum of human diseases, begins by forming double membrane autophagosomes that engulf cytosolic cargo and ends by fusing autophagosomes with lysosomes for degradation(1,2). Membrane fusion activity is required for early biogenesis of...

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Udgivet i:Nature
Main Authors: Diao, Jiajie, Liu, Rong, Rong, Yueguang, Zhao, Minglei, Zhang, Jing, Lai, Ying, Zhou, Qiangjun, Wilz, Livia M., Li, Jianxu, Vivona, Sandro, Pfuetzner, Richard A., Brunger, Axel T., Zhong, Qing
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442024/
https://ncbi.nlm.nih.gov/pubmed/25686604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14147
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