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The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation

The biogenesis of double-membrane vesicles called autophagosomes, which sequester and transport intracellular material for degradation in lysosomes or vacuoles, is a central event in autophagy. This process requires a unique set of factors called autophagy-related (Atg) proteins. The Atg proteins as...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kotani, Tetsuya, Kirisako, Hiromi, Koizumi, Michiko, Ohsumi, Yoshinori, Nakatogawa, Hitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187169/
https://ncbi.nlm.nih.gov/pubmed/30254161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806727115
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