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Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure
In autophagy, Atg proteins organize the pre-autophagosomal structure (PAS) to initiate autophagosome formation. Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosp...
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| Pubblicato in: | eLife |
|---|---|
| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6405243/ https://ncbi.nlm.nih.gov/pubmed/30810528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43088 |
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