Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure

In autophagy, Atg proteins organize the pre-autophagosomal structure (PAS) to initiate autophagosome formation. Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosp...

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Bibliographic Details
Published in:eLife
Main Authors: Harada, Kumi, Kotani, Tetsuya, Kirisako, Hiromi, Sakoh-Nakatogawa, Machiko, Oikawa, Yu, Kimura, Yayoi, Hirano, Hisashi, Yamamoto, Hayashi, Ohsumi, Yoshinori, Nakatogawa, Hitoshi
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405243/
https://ncbi.nlm.nih.gov/pubmed/30810528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43088
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