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In vivo CRISPR screens reveal potent driver mutations in head and neck cancers

We have recently tested the transforming potential of 484 ‘long-tail’ genes, which are recurrently albeit infrequently mutated in head and neck cancers (HNSCC). We identified 15 novel tumor suppressors and our top hits converge on regulating the NOTCH signaling pathway. Therapeutic approaches activa...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Loganathan, Sampath Kumar, Schramek, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469622/
https://ncbi.nlm.nih.gov/pubmed/32944620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1758541
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