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Hyaluronic acid promotes Lgr5(+) stem cell proliferation and crypt fission through TLR4 and PGE(2) transactivation of EGFR
Hyaluronic acid (HA), a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). We previously demonstrated that both CD44 and TLR4, but predominately TLR4, mediated HA stimulation of Lgr5(+) stem cell proliferation, crypt fission, and intestinal growth in postna...
Enregistré dans:
| Publié dans: | Am J Physiol Gastrointest Liver Physiol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7468757/ https://ncbi.nlm.nih.gov/pubmed/32538139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00242.2019 |
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