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Hyaluronic acid binding to TLR4 promotes proliferation and blocks apoptosis in colon cancer

Hyaluronic acid (HA), a constituent of the extracellular matrix, promotes colorectal cancer (CRC) growth. CD44 is a relevant HA receptor in this context. However, HA is also a ligand for TLR4, a receptor of significance in CRC. In this study we examine the relative contribution of HA interactions wi...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Makkar, Sarbjeet, Riehl, Terrence E., Chen, Baosheng, Yan, Yan, Alvarado, David M., Ciorba, Matthew A., Stenson, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891171/
https://ncbi.nlm.nih.gov/pubmed/31484704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1225
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