High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis

Cellular senescence is an irreversible cell growth arrest and is associated with aging and age-related diseases. High plasma phosphate (Pi) and deficiency of Klotho contribute to aging and kidney fibrosis, a pathological feature in the aging kidney and chronic kidney disease. This study examined the...

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書目詳細資料
發表在:Front Pharmacol
Main Authors: Maique, Jenny, Flores, Brianna, Shi, Mingjun, Shepard, Sierra, Zhou, Zhiyong, Yan, Shirely, Moe, Orson W., Hu, Ming Chang
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468469/
https://ncbi.nlm.nih.gov/pubmed/32973510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01273
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