High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis

Cellular senescence is an irreversible cell growth arrest and is associated with aging and age-related diseases. High plasma phosphate (Pi) and deficiency of Klotho contribute to aging and kidney fibrosis, a pathological feature in the aging kidney and chronic kidney disease. This study examined the...

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Vydáno v:Front Pharmacol
Hlavní autoři: Maique, Jenny, Flores, Brianna, Shi, Mingjun, Shepard, Sierra, Zhou, Zhiyong, Yan, Shirely, Moe, Orson W., Hu, Ming Chang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468469/
https://ncbi.nlm.nih.gov/pubmed/32973510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01273
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