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Enantioselective Hydroamination of Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer

An enantioselective, radical-based method for the intramolecular hydroamination of alkenes with sulfonamides is reported. These reactions are proposed to proceed via N-centered radicals formed by proton-coupled electron transfer (PCET) activation of sulfonamide N–H bonds. Non-covalent interactions b...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Roos, Casey B., Demaerel, Joachim, Graff, David E., Knowles, Robert R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468321/
https://ncbi.nlm.nih.gov/pubmed/32182054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c01332
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