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Accurate quantification of copy-number aberrations and whole-genome duplications in multi-sample tumor sequencing data

Copy-number aberrations (CNAs) and whole-genome duplications (WGDs) are frequent somatic mutations in cancer but their quantification from DNA sequencing of bulk tumor samples is challenging. Standard methods for CNA inference analyze tumor samples individually; however, DNA sequencing of multiple s...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Zaccaria, Simone, Raphael, Benjamin J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468132/
https://ncbi.nlm.nih.gov/pubmed/32879317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17967-y
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