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Hippocampal alterations in glutamatergic signaling during amyloid progression in AβPP/PS1 mice

Our previous research demonstrated that soluble amyloid-β (Aβ)(42), elicits presynaptic glutamate release. We hypothesized that accumulation and deposition of Aβ altered glutamatergic neurotransmission in a temporally and spatially dependent manner. To test this hypothesis, a glutamate selective mic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hascup, Kevin N., Findley, Caleigh A., Sime, Lindsey N., Hascup, Erin R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467928/
https://ncbi.nlm.nih.gov/pubmed/32879385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71587-6
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