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Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly
Holoprosencephaly (HPE), a defect in midline patterning of the forebrain and midface, arises ~1 in 250 conceptions. It is associated with predisposing mutations in the Nodal and Hedgehog (HH) pathways, with penetrance and expressivity graded by genetic and environmental modifiers, via poorly underst...
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| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7467722/ https://ncbi.nlm.nih.gov/pubmed/32876567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60351 |
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