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Rescue of Holoprosencephaly in Fetal Alcohol-Exposed Cdon Mutant Mice by Reduced Gene Dosage of Ptch1
Holoprosencephaly (HPE) is a commonly occurring developmental defect in which midline patterning of the forebrain and midface is disrupted. Sonic hedgehog (SHH) signaling is required during multiple stages of rostroventral midline development, and heterozygous mutations in SHH pathway components are...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2013
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3823703/ https://ncbi.nlm.nih.gov/pubmed/24244464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079269 |
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