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Cdon Mutation and Fetal Ethanol Exposure Synergize to Produce Midline Signaling Defects and Holoprosencephaly Spectrum Disorders in Mice
Holoprosencephaly (HPE) is a remarkably common congenital anomaly characterized by failure to define the midline of the forebrain and midface. HPE is associated with heterozygous mutations in Sonic hedgehog (SHH) pathway components, but clinical presentation is extremely variable and many mutation c...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469434/ https://ncbi.nlm.nih.gov/pubmed/23071453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002999 |
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