DNMT1-mediated Foxp3 gene promoter hypermethylation involved in immune dysfunction caused by arsenic in human lymphocytes

Growing evidence indicates that arsenic can cause long-lasting and irreversible damage to the function of the human immune system. It is known that forkhead box protein 3(Foxp3), which is specifically expressed in regulatory T cells (Tregs), plays a decisive role in immunoregulation and is regulated...

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Publicado en:Toxicol Res (Camb)
Autores principales: Ma, Yemei, Ye, Ying, Liu, Yining, Chen, Jing, Cen, Yanli, Chen, Wenyan, Yu, Chun, Zeng, Qibing, Zhang, Aihua, Yang, Guanghong
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
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Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467266/
https://ncbi.nlm.nih.gov/pubmed/32905139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxres/tfaa056
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