Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation

CDK5/p25 kinase plays a major role in neuronal functions, and is hyperactivated in several human cancers including glioblastoma and neurodegenerative pathologies such as Alzheimer's and Parkinson's. CDK5 therefore constitutes an attractive pharmacological target. Since the successful disco...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Chem
Päätekijät: Peyressatre, Marion, Arama, Dominique Patomo, Laure, Arthur, González-Vera, Juan A., Pellerano, Morgan, Masurier, Nicolas, Lisowski, Vincent, Morris, May C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2020
Aiheet:
Chemistry
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7466635/
https://ncbi.nlm.nih.gov/pubmed/32974274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00691
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