Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation

CDK5/p25 kinase plays a major role in neuronal functions, and is hyperactivated in several human cancers including glioblastoma and neurodegenerative pathologies such as Alzheimer's and Parkinson's. CDK5 therefore constitutes an attractive pharmacological target. Since the successful disco...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Peyressatre, Marion, Arama, Dominique Patomo, Laure, Arthur, González-Vera, Juan A., Pellerano, Morgan, Masurier, Nicolas, Lisowski, Vincent, Morris, May C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7466635/
https://ncbi.nlm.nih.gov/pubmed/32974274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00691
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