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Oncogenic Serine 45-Deleted β-Catenin Remains Susceptible to Wnt Stimulation and APC Regulation in Human Colonocytes

The Wnt/β-catenin signaling pathway is deregulated in nearly all colorectal cancers (CRCs), predominantly through mutation of the tumor suppressor Adenomatous Polyposis Coli (APC). APC mutation is thought to allow a “just-right” amount of Wnt pathway activation by fine-tuning β-catenin levels. While...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Parker, Taybor W., Rudeen, Aaron J., Neufeld, Kristi L.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464804/
https://ncbi.nlm.nih.gov/pubmed/32751567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082114
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