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APC-mediated downregulation of β-catenin activity involves nuclear sequestration and nuclear export
Mutational inactivation of adenomatous polyposis coli (APC) initiates most colon carcinomas. APC functions include targeting cytoplasmic β-catenin, a Wnt pathway mediator, for proteolysis. Although APC shuttles between cytoplasm and nucleus, the role of nuclear APC protein, particularly with respect...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2000
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083789/ https://ncbi.nlm.nih.gov/pubmed/11263497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd117 |
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