טוען...
APC-mediated downregulation of β-catenin activity involves nuclear sequestration and nuclear export
Mutational inactivation of adenomatous polyposis coli (APC) initiates most colon carcinomas. APC functions include targeting cytoplasmic β-catenin, a Wnt pathway mediator, for proteolysis. Although APC shuttles between cytoplasm and nucleus, the role of nuclear APC protein, particularly with respect...
שמור ב:
| Main Authors: | , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2000
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083789/ https://ncbi.nlm.nih.gov/pubmed/11263497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd117 |
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