mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells

Epidermal Growth Factor receptor (EGFR) is a tyrosine kinase receptor widely expressed on the surface of numerous cell types, which activates several downstream signalling pathways involved in cell proliferation, migration and survival. EGFR alterations, such as overexpression or mutations, have bee...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Colella, Barbara, Colardo, Mayra, Iannone, Gianna, Contadini, Claudia, Saiz-Ladera, Cristina, Fuoco, Claudia, Barilà, Daniela, Velasco, Guillermo, Segatto, Marco, Di Bartolomeo, Sabrina
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464593/
https://ncbi.nlm.nih.gov/pubmed/32823532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082266
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