Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP

Resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis represents the major hurdle to the clinical use of TRAIL or its derivatives. The discovery and development of lead compounds able to sensitize tumor cells to TRAIL-induced cell death is th...

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Vydáno v:Cells
Hlavní autoři: Elmallah, Mohammed I. Y., Cogo, Sheron, Constantinescu, Andrei A., Elifio-Esposito, Selene, Abdelfattah, Mohammed S., Micheau, Olivier
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464567/
https://ncbi.nlm.nih.gov/pubmed/32708048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9081760
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