Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols

A series of 2-aryl-3-azolyl-1-indolyl-propan-2-ols was designed as new analogs of fluconazole (FLC) by replacing one of its two triazole moieties by an indole scaffold. Two different chemical approaches were then developed. The first one, in seven steps, involved the synthesis of the key intermediat...

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Detalhes bibliográficos
Publicado no:Pharmaceuticals (Basel)
Main Authors: Lebouvier, Nicolas, Pagniez, Fabrice, Na, Young Min, Shi, Da, Pinson, Patricia, Marchivie, Mathieu, Guillon, Jean, Hakki, Tarek, Bernhardt, Rita, Yee, Sook Wah, Simons, Claire, Lézé, Marie-Pierre, Hartmann, Rolf W., Mularoni, Angélique, Le Baut, Guillaume, Krimm, Isabelle, Abagyan, Ruben, Le Pape, Patrice, Le Borgne, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464559/
https://ncbi.nlm.nih.gov/pubmed/32784450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13080186
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