Impact of Hypoxia on Carbon Ion Therapy in Glioblastoma Cells: Modulation by LET and Hypoxia-Dependent Genes

Tumor hypoxia is known to limit the efficacy of ionizing radiations, a concept called oxygen enhancement ratio (OER). OER depends on physical factors such as pO(2) and linear energy transfer (LET). Biological pathways, such as the hypoxia-inducible transcription factors (HIF), might also modulate th...

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Gepubliceerd in:Cancers (Basel)
Hoofdauteurs: Valable, Samuel, Gérault, Aurélie N., Lambert, Gaëlle, Leblond, Marine M., Anfray, Clément, Toutain, Jérôme, Bordji, Karim, Petit, Edwige, Bernaudin, Myriam, Pérès, Elodie A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464439/
https://ncbi.nlm.nih.gov/pubmed/32718037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082019
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