Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products

Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability...

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Publicat a:Pharmaceutics
Autors principals: Lima, Ana Luiza, Pinho, Ludmila A. G., Chaker, Juliano A., Sa-Barreto, Livia L., Marreto, Ricardo Neves, Gratieri, Tais, Gelfuso, Guilherme M., Cunha-Filho, Marcilio
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464369/
https://ncbi.nlm.nih.gov/pubmed/32824475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12080779
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