Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...

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Bibliografski detalji
Izdano u:Pharmaceutics
Glavni autori: Pinho, Ludmila A. G., Souza, Saulo G., Marreto, Ricardo N., Sa-Barreto, Livia L., Gratieri, Tais, Gelfuso, Guilherme M., Cunha-Filho, Marcilio
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160995/
https://ncbi.nlm.nih.gov/pubmed/30134594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10030135
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