ロード中...
AT101 [(-)-Gossypol] Selectively Inhibits MCL1 and Sensitizes Carcinoma to BH3 Mimetics by Inducing and Stabilizing NOXA
Anti-apoptotic BCL2 proteins are important targets for cancer therapy as cancers depend on their activity for survival. Direct inhibitors of MCL1 have entered clinical trials, although their efficacy may be limited by toxicity. An alternative approach may be to induce the pro-apoptotic protein NOXA...
保存先:
| 出版年: | Cancers (Basel) |
|---|---|
| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2020
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7464284/ https://ncbi.nlm.nih.gov/pubmed/32824203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082298 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|