Activation of Epidermal Growth Factor Receptor Sensitizes Glioblastoma Cells to Hypoxia-Induced Cell Death

Background: The epidermal growth factor receptor (EGFR) signaling pathway is genetically activated in approximately 50% of glioblastomas (GBs). Its inhibition has been explored clinically but produced disappointing results, potentially due to metabolic effects that protect GB cells against nutrient...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Luger, Anna-Luisa, Lorenz, Nadja I., Urban, Hans, Divé, Iris, Engel, Anna L., Strassheimer, Florian, Dettmer, Katja, Zeiner, Pia S., Shaid, Shabnam, Struve, Nina, Kriegs, Malte, Hofmann, Ute, Oefner, Peter J., Harter, Patrick N., Steinbach, Joachim P., Ronellenfitsch, Michael W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464192/
https://ncbi.nlm.nih.gov/pubmed/32756332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082144
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