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Second Generation mTOR Inhibitors as a Double-Edged Sword in Malignant Glioma Treatment

Glioblastomas (GBs) frequently display activation of the epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR). mTOR exists as part of two multiprotein complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). In GBs, mTORC1 inhibitors such as rapamycin have performed poorly in c...

詳細記述

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書誌詳細
出版年:Int J Mol Sci
主要な著者: Heinzen, Dennis, Divé, Iris, Lorenz, Nadja I., Luger, Anna-Luisa, Steinbach, Joachim P., Ronellenfitsch, Michael W.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770420/
https://ncbi.nlm.nih.gov/pubmed/31510109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20184474
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