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Second Generation mTOR Inhibitors as a Double-Edged Sword in Malignant Glioma Treatment
Glioblastomas (GBs) frequently display activation of the epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR). mTOR exists as part of two multiprotein complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). In GBs, mTORC1 inhibitors such as rapamycin have performed poorly in c...
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| 出版年: | Int J Mol Sci |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6770420/ https://ncbi.nlm.nih.gov/pubmed/31510109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20184474 |
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