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The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma
BACKGROUND: Despite significant advances in the understanding of glioblastoma genetics and biology, survival is still poor. Hypoxia and nutrient depletion in the tumour microenvironment induce adaptive signalling and metabolic responses, which can influence sensitivity to therapeutic regimens. DNA d...
Guardat en:
| Publicat a: | Br J Cancer |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6461855/ https://ncbi.nlm.nih.gov/pubmed/30745581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0368-3 |
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