Serine-dependent redox homeostasis regulates glioblastoma cell survival

BACKGROUND: The amino acid serine is an important substrate for biosynthesis and redox homeostasis. We investigated whether glioblastoma (GBM) cells are dependent on serine for survival under conditions of the tumour microenvironment. METHODS: Serine availability in GBM cells was modulated pharmacol...

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Udgivet i:Br J Cancer
Main Authors: Engel, Anna L., Lorenz, Nadja I., Klann, Kevin, Münch, Christian, Depner, Cornelia, Steinbach, Joachim P., Ronellenfitsch, Michael W., Luger, Anna-Luisa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188854/
https://ncbi.nlm.nih.gov/pubmed/32203214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0794-x
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