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Conformational Equilibrium of NADPH–Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH–cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antioxidants (Basel)
Prif Awduron: Sugishima, Masakazu, Taira, Junichi, Sagara, Tatsuya, Nakao, Ryota, Sato, Hideaki, Noguchi, Masato, Fukuyama, Keiichi, Yamamoto, Ken, Yasunaga, Takuo, Sakamoto, Hiroshi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464098/
https://ncbi.nlm.nih.gov/pubmed/32731542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9080673
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