Alternative cyanide-binding modes to the haem iron in haem oxygenase

Cyanide is a well known potent inhibitor of haem proteins, including haem oxygenase (HO). Generally, cyanide coordinates to the ferric haem iron with a linear binding geometry; the Fe—C—N angle ranges from 160 to 180°. The Fe—­C—N angle observed in the crystal structure of haem–HO bound to cyanide p...

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Bibliografiska uppgifter
Huvudupphovsmän: Sugishima, Masakazu, Oda, Kenji, Ogura, Takashi, Sakamoto, Hiroshi, Noguchi, Masato, Fukuyama, Keiichi
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2007
Ämnen:
Protein Structure Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335079/
https://ncbi.nlm.nih.gov/pubmed/17554165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S174430910702475X
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