Alternative cyanide-binding modes to the haem iron in haem oxygenase

Cyanide is a well known potent inhibitor of haem proteins, including haem oxygenase (HO). Generally, cyanide coordinates to the ferric haem iron with a linear binding geometry; the Fe—C—N angle ranges from 160 to 180°. The Fe—­C—N angle observed in the crystal structure of haem–HO bound to cyanide p...

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Bibliographic Details
Main Authors: Sugishima, Masakazu, Oda, Kenji, Ogura, Takashi, Sakamoto, Hiroshi, Noguchi, Masato, Fukuyama, Keiichi
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2007
Subjects:
Protein Structure Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335079/
https://ncbi.nlm.nih.gov/pubmed/17554165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S174430910702475X
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